Patient Journey e Impatto dei sintomi:

Armstrong I. Biilings C, Kiely D et al. The patient experience of pulmonary hypertension: a large cross-sectional study of UK patients. BMC Pulmonary Medicine (2019) 19:67

Kingman M, Hinzmann B, Sweet O, Vachieéry JL. Living with pulmonary hypertension: unique insights from an international ethnographic study. bmjopen-2013-004735).

Voice of the Patient, A series of reports from the U.S. Food and Drug
Administration’s (FDA’s) Patient-Focused Drug Development Initiative. Pulmonary Arterial Hypertension. vai al sito

Stile di vita | Alimentazione:

Atteritano M, Santoro D, Corallo G et al. Skin Involvement and Pulmonary Hypertension Are Associated with Vitamin D Insufficiency in Scleroderma. Int J Mol Sci. 2016 Dec 14;17(12). pii: E2103.

Callejo M, Barberá JA, Duarte J et al. Impact of Nutrition on Pulmonary Arterial Hypertension. Nutrients. 2020 Jan 7;12(1). pii: E169.

CREA (Consiglio per la Ricerca in Agricoltura e Analisi dell’Economia Agraria). Linee guida per una sana alimentazione (revisione 2018).

Demir M, Uyan U, Keçeoçlu S, Demir C. The relationship between vitamin D deficiency and pulmonary hypertension. Prague Med Rep. 2013;114(3):154-61.

Kupari M, Rapola J. Reversible pulmonary hypertension associated with vitamin C deficiency. Chest. 2012 Jul;142(1):225-227.

Matori, H.; Umar, S.; Nadadur, R.D. et al. Genistein, a soy phytoestrogen, reverses severe pulmonary hypertension and prevents right heart failure in rats. Hypertension. 2012;60:425–430.

Ruiter, G.; Lankhorst, S.; Boonstra, A. et al. Iron deficiency is common in idiopathic pulmonary arterial hypertension. Eur. Respir. J. 2011;37:1386–1391.

Valentova M, Von Haehling S, Krause C, et al. Cardiac cachexia is associated with right ventricular failure and liver dysfunction. Int J Cardiol. 2013;169:219–224.

Vinke P, Jansen SM, Witkamp RF et al. Increasing quality of life in pulmonary arterial hypertension: is there a role for nutrition? Heart Failure Reviews. 2018; 23:711–722.

Zamanian RT, Hansmann G, Snook S et al. Insulin resistance in pulmonary arterial hypertension. Eur Respir J. 2010;33:318–324.

Stile di vita | Esercizio fisico:

Arena R, Cahalin LP, Borghi-Silva A et al. The effect of exercise training on the pulmonary arterial system in patients with pulmonary hypertension. Prog Cardiovasc Dis 2015;57: 480–488.

de Man FS, Van Hees HW, Handoko ML, et al. Diaphragm muscle fiber weakness in pulmonary hypertension. Am J Respir Crit Care Med 2011;183: 1411-8.

Galiè N, Corris PA, Frost A, et al. Updated treatment algorithm of pulmonary arterial hypertension. JACC 2013; 62: D60-72.

González-Saiz L, Santos-Lozano A, Fiuza-Luces C. Physical activity levels are low in patients with pulmonary hypertension. Ann Transl Med 2018;6(11):205.

Grünig E, Maier F, Ehlken N, et al. (Exercise training in pulmonary arterial hypertension associated with connective tissue diseases. Arthritis Res Ther 2012;14:R148.

Grünig E, Ehlken N, Ghofrani A, Staehler G et al. Effect of exercise and respiratory training on clinical progression and survival in patients with severe chronic pulmonary hypertension. Respiration 2011;81:394–401.

Mereles D, Ehlken N, Kreuscher S, et al. Exercise and respiratory training improve exercise capacity and quality of life in patients with severe chronic pulmonary hypertension. Circulation. 2006;114:1482-9.

Nagel C, Prange F, Guth S, et al. Exercise training improves exercise capacity and quality of life in patients with inoperable or residual chronic thromboembolic pulmonary hypertension. PLoS One. 2012;7:e41603.

PHA (Pulmonary Hypertension Association) Consensus statement, 2008. Recommendations for Exercise in Patients with PAH.

Richter MJ, Grimminger J, Kruger B et al. Effects of exercise training on pulmonary hemodynamics, functional capacity and inflammation in pulmonary hypertension. Pulmonary Circulation 2017;7(1):20–37.

Späte U, Schulze PC. Proinflammatory cytokines and skeletal muscle. Curr Opin Clin Nutr Metab Care. 2004;7: 265-9.

Stile di vita | Esercizio fisico:

Ahmedzai S, Balfour-Lynn M, BewickT, et al. Managing passengers with stable respiratory disease planning air travel: British Thoracic Society recommendations Thorax 2011;66:i1ei30.

Burns RM, Peacock AJ, Johnson M.K. Church A.C. Hypoxaemia in patients with pulmonary arterial hypertension during simulated air travel Respiratory Medicine (2013) 107, 298e304.

Grünig E, Benjamin N, Krüger U, et al. General measures and supportive therapy for pulmonary arterial hypertension: Updated recommendations from the Cologne Consensus Conference 2018. International Journal of Cardiology 272 (2018) 30–36.